The following prescription is received in a community pharmacy:
Losec & #174; 20 mg
S: Take 1 tab BID
M: 2 weeks
Which of the following is correct labelling for this prescription?
Auxiliary labels which should be used on cotrimoxazole suspension include which of the following?
I Shake well before using
II Take with plenty of fluids
III Exposure to sunlight may cause adverse reactions
True statements regarding transcription include which of the following?
I The enzyme responsible for initiating transcription is RNA polymerase.
II The genetic information contained in the nucleotide sequence of mRNA is translated into a protein structure.
III The information carried in the gene sequence is transferred to RNA.
Correct statements regarding Pellagra include:
I- Caused due to deficiency of niacin
II- Caused by failure in converting tryptophan to niacin
III- Characterized by dermatitis, diarrhea and dementia
Which of the following statements best describes the action of the antitubercular agent ISONIAZID?
Otitis media is an ear infection normally caused by S. pneumoniae and may be best treated by:
Gonorrhea, a sexually transmitted disease may be treated by which of the following agents?
I- Cefixime
II- Ceftriaxone
III- Ciprofloxacin
Drug used together with chloroquine in the treatment of malaria with the purpose to kill persistants parasites in the liver of a person infected with Plasmodium vivax is:
Treatment of large intestine infection mainly caused by food intoxication may include:
I- Lots of fluids
II- Ciprofloxacin
III- Metronidazole
Which of the following agents is the best choice of treatment for an asthma patient with rheumatoid arthritis who is considered to have aspirin sensitivity?
When evaluating patients with angina for possible development of nitrate tolerance, true statements include:
I tolerance is rarely associated with isosorbide dinitrate.
II tolerance does not occur in patients who are concurrently on
metoprolol.
III tolerance is dependent upon the administration schedule of nitrate medication.
In deciding what drugs are appropriate for its formulary, the hospital must consider a drug ' s efficacy, associated workload, and acquisition cost. Several new antifungal IV drugs (drug A, drug B, drug C, and drug D), all with equal efficacy, have recently become available.
Currently the hospital stocks drug E, which has been available for several years. Data for the medications is as follows:
DrugCost/DayDosing FrequencyTreatment Duration (days)A$2.50QID14B$2.25once daily14C$5.00BID7D$2.25BID7E$2 .25QID7The most appropriate choice for the hospital is:
Which is the correct start dose of methothrexate in the treatment of rheumatoid arthritis?
Aerosol OT (AOT) is used in veterinary medicine as a laxative. If 250 g of AOT is dissolved in 1 000 mL of glycerin (density of glycerin is 1.25 g/mL), the concentration of AOT in the solution is:
All of the following drugs will increase the heart rate directly or by reflex when injected intravenously into a young healthy adult, EXCEPT:
Structure-activity studies of cholinergic drugs indicate that:
I maximum activity is achieved when the quaternary nitrogen is three carbons removed from the ester oxo group.
II structures which display a quasi-ring conformation exhibit muscarinic activity.
III one methyl group of the trimethylammonium group can be replaced by an ethyl group with only slight loss of activity.
Rx Timolol 0.25% dropsMitte: 15 mLSig: gtt. i o.d. BIDOn the prescription label the instructions to the patient should read:
Which financial statement could be used to determine the total value of prescription drug sales for a pharmacy during the course of a year?
All are β2-agonists used as brochodilators in the treatment of bronchospasm, EXCEPT:
The style of management in which the owner of a pharmacy emphasizes the development of detailed policies and written procedures for employees to observe at all times is referred to as:
Correct administration of Penicillamine in the treatment of rheumatois arthritis include:
Five subjects given a single intravenous dose of a drug have the following elimination half-lives: 3, 9, 6, 5 and 4 h (hours). The mean half-life is:
The fraction of bound receptors in a well-defined drug-receptor binding system is determined by:
I the equilibrium drug-receptor dissociation constant
II the free drug concentration
III the total receptor concentration
The organophosphates commonly found in insecticides are thought to act by which of the following mechanisms?
Bioavailability is related to which of the following parameters, according to the equation F = 1 - E
Which of the following drugs is associated with the reaction of Stevens-Johnson syndrome?
For the majority of drugs, which of the following equations correctly defines clearance?
Which of the following is not directly related to a drug toxicity of Ibuprofen?
Which of the following drugs is associated with the reaction of extreme photosensitivity?
Which of the following drugs is associated with the reaction of Tendon dyfunction?
Which Cytochrome P450 isozyme does not participate appreciably in drug metabolism?
All of the following statements are true regarding chronic inflammation, EXCEPT:
Which of the following is considered the FIRST precursor of vitamin A formation?
The anatomical divisions of the small intestine include the:
I jejunum
II ileum
III duodenum
Which of the followings are types of RNA?
I- RNAt - RNA transferase
II- RNAm – RNA mensager
III-RNAr – RNA ribossome
Diazepam Injection U.S.P
Diazepam 5 mg/ml
Ethanol 10%
Propylene glycol 40%
Benzyl alcohol 1.5%
Water for Injection qs 100%
In the formulation given above, the following ingredient(s) function(s) as a cosolvent(s):
I ethanol
II propylene glycol
III benzyl alcohol
Mercapturic acid derivatives in phase II metabolism can result from reactions of:
Atropine is the primary example of an important class of muscarinic antagonists which are esters of tropic acid and which contain:
Which of the following reactions is controlled by the pancreatic hormone INSULIN?
In the typical cell, mitochondria may contain:
I- Enzymes of Kreb’s cycle
II- Enzymes of respiratory pathway as well cytochrome oxidase
III- Enzymes of fatty acid cycle
Identify the correct pathway of blood flow from the small intestine to the liver:
Gamma aminobutyric acid (GABA. is:
I the major inhibitory neurotransmitter in the brain
II found primarily in interneurons
III synthesized from glycine
If the pKa of phenobarbital is 7.4, what approximate fraction of the drug would be ionized at pH 8.4?
Diseases which are viral infections include:
I poliomyelitis
II rabies
III Legionnaires ' disease
Bacterial resistance to an antibiotic may occurs due to:
I- Mutation
II- Adaptation
III- Gene transfer
In cardiovascular physiology, LaPlace ' s law relates the tension achieved in a blood vessel wall to:
I the length of the vessel
II the radius of vessel
III the intraluminal pressure
Which of the following is the only polysaccharide NOT synthesized during human metabolism?
The codon sequence Adenine-Guanine-Cytosine-Uracil is seen in
I- RNAs
II- DNAs
III- Both DNAs and RNAs
Which of the following is an anti-infective agent with lowest therapeutic index?
Which of the following statement is RIGHT regarding influenza treatment?
I- Type A influenza is best treated by amantadine and rimantadine
II- Type B influenza is best treated by oseltamivir and zenamivir
III- Influenza should not be treated with antiviral agents
Which of the following complications is considered the gravest side effect associated with isoniazid treatment?
Which of the following agents may interfere with the regular effect of penicillins?
Nosocomial infections may be best treated by which of the following agents?
I- Cephalosporin 3rd generation
II- Macrolides antibiotics
III- Penicillins